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Abstract #4005

Effect of Pre-Contrast T1 on the Reproducibility of Liver Perfusion Parameters

Shimon Aronhime1, Claudia Calcagno1, Hadrien Arezki Dyvorne1, Philip Robson1, Henry Rusinek2, Maria Isabel Fiel3, Douglas Dieterich3, Bachir Taouli1

1Radiology, Mount Sinai School of Medicine, New York, United States; 2Radiology, New York University, New York, United States; 3Department of Medicine/Liver Disease, Mount Sinai School of Medicine, New York, United States

Perfusion changes observed in liver fibrosis and cirrhosis can be quantified with perfusion-weighted MRI and a pharmacokinetic model. In this preliminary study, we have assessed the reproducibility of liver perfusion metrics using techniques aimed at optimizing the conversion of signal intensity to gadolinium concentration during 3D T1 perfusionweighted MRI of the liver. All conversion techniques proved to have acceptable to poor reproducibility with no significant difference in reproducibility between the different conversion techniques. These early results indicate that reproducibility of liver perfusion parameters is not affected by the method of gadolinium concentration calculation.