Henry Tam1, Toni Wallace1, Erica Scurr1, David J. Collins2, Ian Chau3, David Cunningham3, Martin O. Leach4, Dow-Mu Koh1
1Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2CRUK and EPSRC, Sutton, Surrey, United Kingdom; 3Oncology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 4Institute of Cancer Research, Sutton, Surrey, United Kingdom
We describe the prevalence and associated imaging findings in patients with colorectal hepatic metastases treated with chemotherapy who demonstrated reticular T1 hypointensity on the hepatocellular phase of Gd-EOB-DTPA enhanced MR imaging. This sign is only observed in patients treated with oxaliplatin based chemotherapy, and is associated with sinusoidal congestion or dilatation at histology. Reticular T1 hypointensity on the hepatocellular phase Gd-EOB-DTPA enhanced imaging appears to be a useful non-invasive sign for sinusoidal congestion resulting from oxaliplatin treatment toxicity in the liver.
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