Clinicopathological Significance of the Peritumoral Decreased Uptake Area of Gd-EOB-DTPA in Hypervascular Hepatocellular Carcinoma: Novel Application of Gd-EOB-DTPA-Enhanced MRI

Akihiro Nishie¹, Yoshiki Asayama¹, Kousei Ishigami¹, Daisuke Kakihara¹, Tomohiro Nakayama¹, Yasuhiro Ushijima¹, Yukihisa Takayama¹, Ken Shirabe¹, Nobuhiro Fujita¹

For the first time we focused on the peritumoral decreased uptake area of Gd-EOB-DTPA (PDUAE) in HCC and investigated the significance of this pseudolesion by comparing variable clinical and pathological factors. As a result, PDUAE was associated with vascular invasion. When the presence of PDUAE was used as an indicator of vascular invasion, relatively high diagnostic performance was obtained. In addition, the vascular invasion of our enrolled cases was microscopic. In general, it remains difficult to detect microscopic vascular invasion on dynamic CT or MRI. Our results suggested that microscopic vascular invasion could be predicted with Gd-EOB-DTPA-enhanced MRI with ease.