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Abstract #4033

Fat Quantification in Liver with 3D Multi-Echo GRE Dixon in a Single Breath-Hold: Comparison with HISTO and 2D Multi-Echo GRE Dixon

Xiaodong Zhong1, Puneet Sharma2, Wesley D. Gilson3, Vladimir Jellus4, Stephan Kannengiesser4, Brian M. Dale5, Berthold Kiefer4, Diego R. Martin2

1MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States; 2Radiology Department, University of Arizona, Tucson, AZ, United States; 3Corporate Research, Siemens Corporation, Baltimore, MD, United States; 4Siemens AG Healthcare Sector, Erlangen, Germany; 5MR R&D Collaborations, Siemens Healthcare, Cary, NC, United States

In this study, a single breath-hold multi-echo 3D GRE Dixon method with whole liver coverage and high slice resolution was developed and preliminary evaluation was performed in clinical patients. This 3D GRE Dixon method produced similar liver fat quantification results to those measured with 2D multi-echo GRE Dixon, and high-speed T2-corrected multiple-echo 1H-MRS (HISTO) as a reference standard, for the protocols and patients tested in this study. This single breath-hold 3D GRE Dixon method may be adopted in the routine clinical scan and have great potential for evaluating the hepatic steatosis for obesity related liver diseases.