Benjamin Leporq1, Helene Ratiney1, Herve Saint-Jalmes2, 3, Frank Pilleul1, 4, Olivier Beuf1
1CREATIS; CNRS UMR 5220; INSERM U1044; INSA-Lyon; UCBL Lyon 1, Villeurbanne, Rhne-Alpes, France; 2LTSI; Inserm U642; Universit Rennes 1, Rennes, Bretagne; 3CRLCC; Centre Eugne Marquis, Rennes, Bretagne, France; 4Hospices civils de Lyon; CHU Edouard Herriot, Lyon, Rhne-Alpes, France
In Western countries, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver diseases. Because NAFLD can evolve into Non-Alcoholic Steato-Hepatitis and may lead to liver fibrosis up to cirrhosis, a clinical follow-up of NAFLD would be valuable. This work presents a MR magnitude-based technique for liver fat volume fraction quantification with independent fat and water T2* estimations, T1-related bias and spectral complexity of fat corrections using a two-angles multiple gradient-echo acquisition. The method described was applied in-vivo at 1.5T in a prospective study and at 3.0T on healthy subjects. It was additionally compared with 1H MRS on fat-water phantoms.