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Abstract #4039

A Systematic Technique for Echo Truncation in MRI-Based R2* Calculations for Liver Iron Quantification Which Reduces Systematic and Random Error

Mustafa Rifaat Bashir1, Brian M. Dale2, Elmar Max Merkle1

1Radiology, Duke University Medical Center, Durham, NC, United States; 2Siemens Medical Solutions, Cary, NC, United States

Multi-echo gradient echo based MRI techniques have emerged as a useful clinical tool for estimating hepatic iron concentration by measuring liver R2*. Systematic and random errors can occur in the R2* solution based on the number of echoes used for the calculation. We explore the propagation of these errors, and propose and analyze a technique for reducing error by selecting an optimized number of echoes for the calculation. We compare this with standard techniques using Monte Carlo simulations and patient data.