An Tang1, 2, Lucas Shanholtzer2, Nikolaus Szeverenyi2, Rohit Loomba3, Michael Peterson4, Tanya Wolfson5, Anthony C. Gamst5, Richard L. Ehman6, Claude B. Sirl
1Radiology, University of Montreal, Montreal, Qc, Canada; 2Radiology, University of California, San Diego, San Diego, CA, United States; 3Division of Gastroenterology, Hepatology, and Medicine, University of California, San Diego, San Diego, CA, United States; 4Department of Pathology, University of California, San Diego, San Diego, CA, United States; 5Biostatistics, University of California, San Diego, San Diego, CA, United States; 6Radiology, Mayo Clinic, Rochester, MN, United States
Liver stiffness was measured by magnetic resonance elastography (MRE) and compared with histology. MRE performed at 3.0 T with 1 axis and 3 axes motion sensitization at multiple frequencies showed strong correlations with fibrosis stage and a trend toward higher stiffness with increasing lobular inflammation grades in adults with NAFLD. These results confirm that MRE is useful for noninvasive assessment of fibrosis not only in a variety of chronic liver disease but also in a population of NAFLD patients.
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