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Abstract #4043

Clinical Comparison of Single-R2* and Dual-R2* Correction for Accurate Fat Quantification in the Liver

MAGNA25Debra E. Horng1, 2, Diego Hernando1, Catherine D.G. Hines3, Scott B. Reeder1, 2

1Radiology, University of Wisconsin-Madison, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 3Merck Research Laboratories, West Point, PA, United States

We compared the performance of fat-fraction quantification using chemical shift encoded MRI using single-R2* and dual-R2* correction methods, using MR spectroscopy (MRS) as the reference standard. From a group of 97 patients, 20 patients with fat fraction > 10% were identified, and chemical shift encoded fat-water imaging was performed. Fat-fraction was measured from the imaging data using both single-R2* and dual-R2* correction. Fat-fraction estimates were compared to co-registered spectroscopy measurements: single-R2* correction demonstrated higher agreement. Single-R2* modeling is more accurate than dual-R2* modeling for hepatic fat quantification in patients, even in those with high hepatic fat concentrations.