Clinical Comparison of Single-R2* and Dual-R2* Correction for Accurate Fat Quantification in the Liver

Debra E. Horng¹, ², Diego Hernando¹, Catherine D.G. Hines³, Scott B. Reeder¹, ²

We compared the performance of fat-fraction quantification using chemical shift encoded MRI using single-R₂* and dual-R₂* correction methods, using MR spectroscopy (MRS) as the reference standard. From a group of 97 patients, 20 patients with fat fraction > 10% were identified, and chemical shift encoded fat-water imaging was performed. Fat-fraction was measured from the imaging data using both single-R2_* and dual-R₂* correction. Fat-fraction estimates were compared to co-registered spectroscopy measurements: single-R₂* correction demonstrated higher agreement. Single-R₂* modeling is more accurate than dual-R₂* modeling for hepatic fat quantification in patients, even in those with high hepatic fat concentrations.