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Abstract #4046

Voxel-Wise Reproducibility of Magnetic Resonance Rheology of the Liver at 3T MRI

Anneloes E. Bohte1, Aart J. Nederveen1, Paul F.C. Groot1, Annikki de Niet2, Peter L.M. Jansen2, Ralph Sinkus3, Jaap Stoker1

1Radiology, Academic Medical Center, Amsterdam, Netherlands; 2Gastroenterology, Academic Medical Center, Amsterdam, Netherlands; 3Radiology, Hpital Beaujon, Paris, France

Liver fibrosis can be detected by means of Magnetic Resonance Rheology (MRR, also known as MR elastography). It has the potential to replace liver biopsy in patients with chronic liver disease. If this measurement becomes part of the clinical routine, one needs to know which changes in liver elasticity and viscosity over time can be accurately measured. In this study we define a threshold for detecting a significant change in both liver elasticity and viscosity in repeated MRR measurements in a group of 27 subjects containing both healthy volunteers and patients with viral hepatitis B/C.