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Abstract #4061

Time Course Study on the Effects of Iodinated Contrast Medium on Intrarenal Water Transport Function Using Diffusion-Weighted MRI

Jing Wang1, Yudong Zhang2, Xuedong Yang2, Xiaoying Wang, 12, Jue Zhang1, 3, Jing Fang1, 3, Xuexiang Jiang2

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Department of Radiology, Peking University First Hospital, Beijing, China; 3College of Engineering, Peking University, Beijing, China

This study is aim to assess the effects of intravenous-injected iodinated contrast medium on intrarenal water diffusion using noninvasive DW-MRI. A sequential DW-MRI was performed on rabbit model to estimate the intrarenal apparent diffusion coefficient at 24 hours before and 1h, 24h, 48h and 72h after administration. As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy.