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Abstract #4063

Intra-Renal Oxygenation by BOLD MRI in Rat Model of Contrast Induced Nephropathy: Evaluation by R2* and R2'

Lu-Ping Li1, Hongyu An2, Tammy Franklin3, Ujala Bokhary3, Anindya Sen3, Pottumarthi V. Prasad3

1Radiology Dept., Northshore University Healthsystem, Evanston, IL , United States; 2Radiology, University of North Carolina, Chapel Hill, NC, United States; 3Radiology Dept., Northshore University Healthsystem, Evanston, IL, United States

R2* is widely used as a renal BOLD MRI parameter, but is inherently dependent on R2 in addition to the susceptibility induced relaxation, R2. R2 can be estimated using asymmetric spin echo (ASE) sequence. Preliminary data from 26 rats were acquired with this sequence before and after administration of iodinated contrast agents in a model of CIN. Our preliminary experience supports the feasibility of acquiring R2 maps using ASE-EPI sequence in kidneys and that the similar trends observed with R2* and R2 suggests that measured changes in R2* are primarily due to changes in susceptibility.