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Abstract #4071

Serial Assessment of Renal Anatomy and Function in Mice with Unilateral Ureteral Obstruction Using Multi-Modal Imaging

C. Chad Quarles1, Feng Weng1, Mohammed Tantawy1, Rosie Jiang2, Keiko Takahashi2, Chuan-Ming Hao2, Todd Peterson1, Raymond Harris2, Takamune Takahashi2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2O'Brien Mouse Kidney Physiology and Disease Center, Vanderbilt University, Nashville, TN, United States

MRI and 99m Tc-MAG3 scintigraphy were used to serially assess the mouse kidney following unilateral ureteral obstruction (UUO). In UUO mice the renal pelvic space gradually expanded in obstructed kidneys as early as 1 day post ureteral ligation and the components of renal medulla, especially inner medulla and papilla, was remarkably decreased as the disease progressed. The 99m Tc-MAG3 data revealed that renal perfusion is remarkably and rapidly reduced in UUO kidneys, whereas it is gradually increased in contra-lateral kidneys. In pre-clinical models of renal disease, these imaging techniques could be effective tools for elucidating pathological mechanisms of obstructive kidney disease.