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Abstract #4077

Evaluation of Imatinib Mesylate as a Possible Treatment for Nephrogenic Systemic Fibrosis in a Rat Model

MAGNA25Thomas A. Hope1, Philip LeBoit2, Whitney A. High3, Yanjun Fu4, Robert C. Brasch4

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Dermatology, UCSF, San Francisco, CA; 3Dermatology, University of Colorado, Denver, CO; 4Radiology, UCSF, San Francisco, CA

We have evaluated the efficacy of imatinib mesylate for the treatment of nephrogenic systemic fibrosis in a high dose GBCA animal model and have demonstrated that the administration of imatinib results in decreased lesion severity suggesting that imatinib may be effective in the treatment of NSF in humans.