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Abstract #4081

Manganese Oxide Doped Gadolinium Oxide Nanoparticles for Both T1 and T2 MRI Contrast Agent

BADRUL ALAM BONY1, Ja Young Park2, Krishna Kattel, Wenlong Xu, Woo Choul Heo, Tirusew Tegafaw Mengesha, Gang Ho Lee

1Chemistry, Kyungpook National University, Daegu, Korea, Republic of; 2Kyungpook National University, Kazakhstan

We have developed ultra-small gadolinium oxide nanoparticles, which are surface-doped with manganese oxide abbreviated as Gd2O3@MnO. In this work, the surface doped gadolinium oxide nanoparticles with an average d of 1 to 2 nm, which can be dispersed homogeneously. They were further coated with hydrophilic biocompatible lactobionic acid. It shows high relaxivity than normal ultrasmall gadolinium oxide nanoparticle. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T1 and T2 map images, showing that the nanoparticles may be used as both T1 and T2 MRI contrast agents.