Manganese Oxide Doped Gadolinium Oxide Nanoparticles for Both T1 and T2 MRI Contrast Agent

BADRUL ALAM BONY¹, Ja Young Park², Krishna Kattel, Wenlong Xu, Woo Choul Heo, Tirusew Tegafaw Mengesha, Gang Ho Lee

We have developed ultra-small gadolinium oxide nanoparticles, which are surface-doped with manganese oxide abbreviated as Gd2O3@MnO. In this work, the surface doped gadolinium oxide nanoparticles with an average d of 1 to 2 nm, which can be dispersed homogeneously. They were further coated with hydrophilic biocompatible lactobionic acid. It shows high relaxivity than normal ultrasmall gadolinium oxide nanoparticle. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T1 and T2 map images, showing that the nanoparticles may be used as both T1 and T2 MRI contrast agents.