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Abstract #4088

Characterization of Diffuse Liver Disease Using the T2 of the Water Component and Fat Fraction

Tomoe Barr1, Phillip Kuo2, Judith Pugh3, Charmi Patel3, Horacio Rilo4, Scott Squire2, Thomas Boyer5, Maria I. Altbach2

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2Radiology, University of Arizona, United States; 3Pathology, University of Arizona, United States; 4Surgery, University of Arizona, United States; 5Medicine, University of Arizona, United States

Chronic liver disease due to Hepatitis B/C infection or non-alcoholic steatohepatitis (NASH) is a major health problem in the USA and worldwide. The diagnosis of these pathologies requires a liver biopsy which is an invasive procedure with associated morbidity and cost and subject to sampling errors. Thus non-invasive imaging methods are actively being sought. In this work we use a novel radial gradient and spin-echo (RADGRASE) method which provides T2 of the water component and fat fraction maps from data acquired in a breath hold. These parameters are used to characterize changes in the liver due to inflammation, fibrosis, and steatosis in subjects with suspected of chronic liver disease.