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Abstract #4108

Impact of the Noise Model on Intra-Voxel Incoherent Motion (IVIM) Parameter Estimates in Abdominal DW-MRI

Moti Freiman1, Jeannette M. Perez-Rossello1, Michael J. Callahan1, Mark Bittman1, Stephan D. Voss1, Robert V. Mulkern1, Simon K. Warfield1

1Radiology, Children's Hospital Boston/Harvard Medical School, Boston, MA, United States

Numerical schemes commonly used to estimate the Intra-voxel incoherent motion (IVIM) model parameters from DW-MRI approximate Rician noise of the signal intensities with a Gaussian noise model which may induce bias in IVIM model parameters estimation. We developed a maximum likelihood estimator (MLR) that accounts for the Rician distributed noise; and assessed the impact of the noise model and numerical algorithm used to estimate IVIM model parameters.