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Abstract #4110

Repeatability of Abdominal Diffusion Weighted MRI: A Phantom & Volunteer Study

Marc Eric Miquel1, 2, Andrew David Scott1, Redha Boubertakh1, Niall Dominic MacDougall1, Nishat Bharwani3, Andrea G. Rockall4

1Clinical Physics, Barts and the London NHS Trust, London, United Kingdom; 2Barts and the London Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, England, United Kingdom; 3Radiology Department, Imperial College Healthcare NHS Trust, London, United Kingdom; 4Department of Imaging, Barts and the London NHS Trust, London, United Kingdom

DW-MRI is potentially a useful cancer biomarker and apparent diffusion coefficient (ADC) could be used to monitor treatment. However, repeatability studies are still limited. We investigated the in-vitro and in-vivo repeatability of a free-breathing abdominal DWI-sequence. The in-vitro coefficient of variation was less than 1.5%. In-vivo, the coefficients of reproducibility were kidney 20%, gallbladder 21%, liver 24.7% and spleen 28.0% when taking into account small regions of interest.. For large volumes of interest, values fall to 7.7, 6.4, 8.6 and 9.6% respectively. If all organs are considered indiscriminately the values are 23.1% for small regions and 7.9% for large volumes.