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Abstract #4112

The Influence of Model Used to Fit DW-MRI Data on Apparent Diffusion Coefficient Estimates and Their Reproducibility in Normal Tissues

Nina Tunariu1, David J. Collins1, Matthew Orton1, James A. d'Arcy1, Veronica A. Morgan1, Sharon L. Giles1, Nandita M. deSouza1

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton, London, United Kingdom

Diffusion Weighted MRI is considered a potential biomarker for anticancer therapy response. The literature suggests that assumption of a simple exponential relationship between signal attenuation and b value for ADC calculation may be too simplistic and that using more complicated mathematical models which account for the non-monoexponential behaviour of the diffusion signal attenuation in tissues results in a better data fitting and potentially less variable ADC estimates. The purpose of this study was to evaluate the influence of the mathematical model used to fit the DW-MRI data on the ADC values and their reproducibility.