Chemical Exchange Sensitive Imaging Without a Long Irradiation Pulse: Irradiation with Toggling Inversion Preparation

Tao Jin¹, Seong-Gi Kim¹

One practical issue for the chemical exchange (CE) based MRI techniques is that the conventional T₁ and T₂ relaxations often contaminate the CE imaging contrast. Another issue is that due to hardware or specific absorption rate limitations, CE-sensitive image often has to be acquired using a short irradiation pulse, although a long pulse reaching the steady state may simplify the quantification and sometimes results in better image contrast. Here we propose a novel acquisition method that can use a relatively short irradiation pulse to remove T₁ and T₂ effects in the CE contrasts, and also to obtain the steady-state imaging contrast.