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Abstract #4193

Altered CEST Spectrum with Different Imaging Readout Schemes

Sheng-Min Huang1, Shang-Yueh Tsai2, Teng-Yi Huang3, Yi-Chun Wu4, Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan; 3Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 4Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

The effect of image acquisition RF pulses on CEST imaging was investigated in this study. RARE and spin-echo EPI were utilized on a phantom experiment. The spillover effect of multiple 180 refocusing RFs was confirmed on the observed Z-spectra. The asymmetry of magnetic transfer ratio was thus reduced while using RARE for imaging acquisition. It is suggested that care must be taken when using RF pulses train for image readout.