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Abstract #4219

A Novel Pulse Sequence to Measure Oxygen Extraction Fraction in the Brain Using Parameter Assessment Using Retrieval from Signal Encoding (Parse) Techniques

Rajiv G. Menon1, Bradley P. Sutton2, Donald B. Twieg3, Timothy J. Carroll1

1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; 2Bioengineering Department, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 3Biomedical Engineering Department, University of Alabama at Birmingham, Birmingham, AL, United States

We propose a novel technique for the measurement of oxygen extraction fraction (OEF) using Parameter Assessment by Retrieval from Signal Encoding (PARSE) techniques. OEF is a key indicator of cerebral perfusion and gives crucial information regarding the stage of vascular compromise in patients with neurovascular disease. PARSE is an efficient, multi-parameter estimation technique, that uses a more accurate signal model to simultaneously measure M0, R2* and local frequency. By direct measurement of local frequency changes due to OEF related susceptibility changes using PARSE, we determine the feasibility of robustly estimating OEF in pathological situations.