A High-Resolution Large-Scale 2D Geometric Magnetic Susceptibility Model of White Matter Microstructure

Way Cherng Chen¹, Sean Foxley¹, Karla Miller¹

Studies have shown that magnetic susceptibility introduces signal changes that are related to white matter tract structure. We previously presented a simple, small-scale 3D geometric model to estimate the microscopic field pattern that is driven by of various aspects of underlying tissue microstructure such as orientation to B0, myelin thickness and tissue iron concentration that can be used to predict susceptibility-based MR contrast. Here, a more robust and flexible 2D geometric model is introduced to allow more physiologically realistic representations of the actual WM microstructure.