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Abstract #4277

A High Resolution High SNR 3D T2prep Spiral Protocol for Robust Whole Brain Myelin Water Quantification at 3 Tesla

Thanh D. Nguyen1, Mitchell Cooper1, 2, Pascal Spincemaille1, Ashish Raj1, Yi Wang1, 2, Susan A. Gauthier3

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Biomedical Engineering, Cornell University; 3Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States

Conventional multi-component T2 relaxometry for myelin water fraction (MWF) mapping in the brain at 1.5T is time-consuming and has limited spatial coverage. The objective of this study is to develop a high resolution and high SNR 3D T2prep spiral protocol for whole brain myelin water mapping at 3T and to evaluate its performance in healthy volunteers by comparing with the conventional 1.5T acquisition. We found no significant changes in MWF between 1.5T and 3T. MWF maps obtained at 3T have lower coefficient of variance and better visualization of WM tracts.