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Abstract #4280

Iron Quantification in Normal Aging Brain Accessed by the MR Signal Decay in the Static Spin Dephasing Regime of Spherical Perturbations

Jan Sedlacik1, Kai Boelmans2, Ulrike Lbel1, Brigitte Holst1, Susanne Siemonsen1, Jens Fiehler1

1Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

MRI is able to quantitatively detect iron deposition by changes in transverse relaxation rates and signal phase. Recently, quantitative susceptibility mapping was used to further extract the underlying magnetic susceptibility from the MR signal phase information. Purpose of this study was to demonstrate that true quantitative iron content can be derived from the transverse relaxation rates by using the analytical model of the static spin dephasing regimen of spherical perturbations. The established control values of iron content in the normal aging brain will serve as control for future clinical studies of neurodegenerative diseases at our institution.