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Abstract #4293

Frequency-Domain Quantification and Interpretation of Dynamic Hyperpolarized 13C Signals

Florian Wiesinger1, Oleksandr Khegai1, 2, Jonathan I. Sperl1, Eliane Weidl2, Axel Haase2, Markus Schwaiger2, Rolf F. Schulte1

1GE Global Research, Munich, Germany; 2Technische Universitaet Muenchen, Munich, Germany

In this work an efficient and novel frequency-domain signal quantification framework is presented for the analysis and interpretation of dynamically acquired hyperpolarized 13C data. The method is used to compare simple signal normalization versus apparent rate constant estimation for dynamically-acquired, slice-selective FID spectra and IDEAL spiral CS imaging animal rat experiments.