Abstract #4298

Differentiation of Flux and Isotopic Exchange Using Co-Administration of Hyperpolarized [2-13C]Pyr and [1-13C]Lac

Jae Mo Park¹,², Ralph E. Hurd³, Sonal Josan²,⁴, Yi-Fen Yen³, Adolf Pfefferbaum⁴,⁵, Dirk Mayer,²⁴, Daniel M. Spielman,¹²

¹Electrical Engineering, Stanford University, Stanford, CA - California, United States; ²Radiology, Stanford University, Stanford, CA - California, United States; ³Applied Science Laboratory, GE Healthcare, Menlo Park, CA - California, United States; ⁴Neuroscience Program, SRI International, Menlo Park, CA - California, United States; ⁵Psychiatry, Stanford University, Stanford, CA - California, United States

Bi-directional metabolic conversion can be estimated by simultaneously injecting both co-polarized substrates. The amount of flux and isotopic exchange can be estimated by the difference in flow of each substrate. We demonstrate the differentiation of flux and isotopic exchange between Pyr and Lac by injecting polarized [2-13C]Pyr and [1-13C]Lac together, and observed increased flux from Pyr to Lac after EtOH infusion.