Combined Parallel and Partial Fourier MR Reconstruction for Accelerated Hyperpolarized 13 in vivo MRSI

Michael Abram Ohliger¹, Peder E. Z. Larson¹, Robert Bok¹, Simon Hu¹, Peter Shin¹, James Tropp², Lucas Carvajal¹, Sarah J. Nelson¹, John Kurhanewicz¹, Daniel

We implement a combined partial Fourier and self-calibrating parallel MR reconstruction for acquisition of hyperpolarized ¹³C spectroscopic imaging in a rat, achieving an added reduction in scan time of 39% when compared with parallel MRI alone. Using an echo planar spectroscopic imaging sequence, we acquire a 30 x 10 x 16 matrix of spectroscopic voxels within 13 s. The shorter scan time is critical to combat signal loss due to T1 decay, metabolism, and RF saturation. In addition, this acquisition enables the time scale and imaging coverage required for human imaging in vivo.