Meeting Banner
Abstract #4307

Combined Parallel and Partial Fourier MR Reconstruction for Accelerated Hyperpolarized 13 in vivo MRSI

Michael Abram Ohliger1, Peder E. Z. Larson1, Robert Bok1, Simon Hu1, Peter Shin1, James Tropp2, Lucas Carvajal1, Sarah J. Nelson1, John Kurhanewicz1, Daniel

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2General Electric Healthcare, Fremont, CA, United States

We implement a combined partial Fourier and self-calibrating parallel MR reconstruction for acquisition of hyperpolarized 13C spectroscopic imaging in a rat, achieving an added reduction in scan time of 39% when compared with parallel MRI alone. Using an echo planar spectroscopic imaging sequence, we acquire a 30 x 10 x 16 matrix of spectroscopic voxels within 13 s. The shorter scan time is critical to combat signal loss due to T1 decay, metabolism, and RF saturation. In addition, this acquisition enables the time scale and imaging coverage required for human imaging in vivo.