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Abstract #4330

Assesment of Diabetic Nephropathy with Hyperpolarised [1-13C]Pyruvate

Christoffer Laustsen1, 2, Jakob Appel stergaard3, Rikke Nrregaard4, Steffen Ringaard1, Niels Chr. Nielsen5, Allan Flyvbjerg3, Michael Pedersen1, Per keson2

1The MR Research Centre, Institute of clinical Medicine, Aarhus University, Aarhus N, Denmark; 2DRCMR, Hvidovre Hospital, Hvidovre, Denmark; 3Department of Endocrinology and Internal Medicine, Aarhus University, Aarhus, Denmark; 4Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark; 5Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark; 6GE Healthcare, Denmark; 7 Department of Electrical Engineering, Technical University of Denmark, Kgs Lyngby, Denmark

A type-1 STZ induced diabetic nephropathy rat model is investigated with hyperpolarized [1- 13C]pyruvate, to allow early diagnosis and monitoring of decreased kidney function, with increased diabetes. We here show the metablic profile of the type 1 diabetic rat, from early diabetes to late diabetes, with a significant altered profile over the time course, showing the decreasing kidney function. The method show great promise for accurate non-invasive metabolic profiling of diabetic patients, with different stages of reduced kidney function.