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Abstract #4334

Simultaneous 13C MR Spectroscopy Measurements of Hyperpolarized [1-13C] Pyruvate in Two Cancer Bearing Mice

Georgios Batsios1, Catherine Germanier1, Marcin Krajewski1, Michael Batel2, Kilian Weiss1, Andreas Sigfridsson1, Markus Rudin1, 3

1Instute for Biomedical Enginnering, ETH and University of Zurich, Zurich, Switzerland; 2Laboratory of Physical Chemistry, ETH, Zurich, Switzerland; 3Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

Hyperpolarized 13C magnetic resonance spectroscopy and imaging is a rapidly expanding field with many applications, in particular in the field of cancer. Due to a variety of reasons preclinical cancer studies are commonly carried out in nude mice, which put limits to the total amount of solution that can be administered intravenously. However, the amount of compounds polarized by commonly used polarizers is significantly larger. To make efficient use of this amount, in the present work we demonstrate the feasibility of parallel monitoring pyruvate metabolism in two animals using a single MR transceiver coil in combination with slice selective excitation.