Synthesis, Characterization, In Vitro and in vivo MR Studies of Dy(OH) 3 Nanostructures for T2 MRI Contrast Agent

Krishna Kattel¹, Ja Young Park¹, Wenlong Xu¹, Badrul Alam Bony¹, Woo Choul Heo¹, Tirusew Tegafaw Mengesha¹, Gang Ho Lee¹

Dy-compounds are promising candidates for MRI contrast agent. Dy³⁺ has the shortest electronic relaxation time and highest magnetic moment (10.6 _B) which induce water proton relaxation that primarily affect T₂. It increases significantly with the external magnetic field, and is proportional to the square of the magnetic moment of the Dy³⁺ ion. Dy(OH) ₃ nanostructures were examined for their possible use in MR imaging and tracking of cells by investigating their cytotoxic behaviors.