DCE-MRI to Study Vascular Dependency of Radiolabelled Nano-Graphene Oxide Nanoparticle Delivery

Bart Cornelissen¹, Veerle Kersemans¹, Philip Allen¹, Sarah Able¹, Sean Smart¹, Katherine Vallis¹

A poly-ethylene-glycol conjugated (PEGylated) form of nano-graphene oxide (NGO) was shown to target tumour xenografts, but its mechanism of tumour targeting is not elucidated yet. Here, we show that DCE-MRI proved a valuable tool to study the biodistribution and tumour delivery characteristics of radiolabelled nano-graphene oxide. Taken together, these results suggest that the tumour uptake of NGO-PEG depends heavily on tumour vascular density and permeability.