Jeffrey Steinberg1, Sendhil Velan1
1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore
Glucose overlaps with several metabolites in the 3.2-3.9 ppm range in a typical spectrum in proton magnetic resonance spectroscopy. In order to resolve the glucose peaks from neighboring peaks, spectra at multiple TE values between 60 and 95 ms were averaged, resulting in a peak and a trough at 3.7 and 3.85 ppm respectively. Using voxels in the hippocampi of six rats, the TE averaged sequence obtained glucose estimates relative to creatine of 0.43 0.07, whereas glucose estimates for data at a TE of 13 ms was 0.37 0.35. The lower standard deviation for TE-averaged data indicates a much more reliable estimate of glucose than the standard short TE PRESS sequence.