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Abstract #4406

The Addition of Rituximab to First-Line Chemotherapy for Newly-Diagnosed Diffuse Large B-Cell Lymphoma Does Not Modify the Prediction of Therapy Outcome by Phosphorus MR Spectroscopy

Fernando Arias-Mendoza1, Kristen Zakian2, Geoffrey S. Payne3, Marion Stubbs4, Hamed Mojahed1, Amita Shukla-Dave2, Franklyn Howe5, Harish Poptani6, Mitchell R. Smith<su

1Columbia University Medical Center, New York, NY, United States; 2Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 3Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom; 4Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom; 5St. George's Hospital, London, United Kingdom; 6University of Pennsylvania Medical Center, Philadelphia, PA, United States; 7Fox Chase Cancer Center, Philadelphia, PA, United States; 8New York University Medical Center, New York, NY, United States; 9Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 10Medical University of South Carolina, Charleston, SC, United States

We have used in vivo phosphorus MR spectroscopy to measure phosphoethanolamine and phosphocholine in tumors of newly diagnosed diffuse large B-cell lymphoma patients prior to the start of first-line chemotherapy and normalized to nucleoside triphosphates (PME/NTP) with the aim to assess whether the correlation of the pretreatment tumor PME/NTP value with treatment outcome differs between those patients treated with first-line chemotherapy alone and those treated with added rituximab.