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Abstract #4416

Investigation of NAA Dynamics Underlying Visual Stimulation Using MEGA-PRESS

Ricardo C. G. Landim1, 2, Richard A. E. Edden3, Bernd Foerster, 24, Li M. Li, 25, Roberto J. M. Covolan1, 2, Gabriela Castellano1, 2

1Institute of Physics Gleb Wataghin, University of Campinas, Campinas, SP, Brazil; 2CInAPCe Program (Cooperao Interinstitucional de Apoio a Pesquisas sobre o Crebro), So Paulo, SP, Brazil; 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, United States; 4Philips Medical Systems, So Paulo, SP, Brazil; 5School of Medical Sciences, University of Campinas, Campinas, SP, Brazil

Possible N-acetyl-aspartate (NAA) variations with stimulation are a controversial discussion topic in the literature. Individual measurement of this metabolite is difficult due to the superposition of its spectrum with N-acetyl-aspartyl-glutamate's (NAAG). We designed a functional MRS experiment using the editing sequence MEGA-PRESS to evaluate the individual dynamics of NAA underlying brain activation during visual stimulation.