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Abstract #4419

Ultra-High-Field Sodium Imaging of the Human Brain at 9.4 Tesla

Sandro Romanzetti1, Daniel Fiege1, Jrg Felder1, Avdo Celik1, Christian Mirkes1, 2, N.Jon Shah1, 3

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; 2Max Planck Institute for Biological Cybernetics, Tbingen, Germany; 3JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Monitoring the strongly regulated sodium content in vivo is of great interest for a variety of diseases. Imaging this nucleus is difficult due to its low concentration and fast relaxation. Using an ultra-high field scanner at 9.4 Tesla, a dedicated RF coils and the efficient Twisted Projection Imaging sequence, 2mm nominal isotropic sodium images of the human brain were acquired. Comparison with an MP-RAGE image shows the fine anatomical details, while a 4T comparison shows the great SNR improvement.