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Abstract #4430

1H Magnetic Resonance Spectroscopy Reports Osmotic Dysregulation in Brain During Whole Body Radiation Induced Radiation Sickness

Poonam Rana1, Ahmad Raza Khan1, Shilpi Modi1, Richa Trivedi1, B.S Hemanth1, Rajendra P. Tripathi1, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Synopsis: Central nervous system is considered a radio-resistant organ during whole body exposure but function changes do occur after radiation exposure in terms of neurochemical metabolism. The present study based on 1H MRS was conducted to look for metabolic changes in mouse brain after giving graded whole body irradiation. The results exhibited time and dose dependent decrease in osmolytes; myoinositol and taurine in cortico-hippocampal region day 3 onwards post irradiation. Decreased levels of both the metabolites suggested oxidative stress induced osmotic dysregulation in brain that could have been associated with functional changes occurring in brain