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Abstract #4433

A Comparative Evaluation of Brain Metabolites Following Whole Body and Cranial Irradiation: A Prospective 1H MRS Study

Poonam Rana1, Mamta Gupta1, Ahmad Raza Khan1, Richa Trivedi1, B.S Hemanth1, Ravi Soni2, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Synopsis: Central nervous system has a limited repertoire of responses to radiation injury and it responds differentially with the type of exposure of radiation given. The present study was conducted to identify metabolic changes in hippocampal region of mice brain after cranial and whole body irradiation using 1H NMR spectroscopy if any. The results exhibited time dependent decrease in two metabolites; myoinositol and taurine in hippocampal region day3 onwards post irradiation only in animals exposed to whole body radiation. While no significant difference in metabolite level was observed in whole brain irradiation. Differential response of whole body and cranial irradiation might be due to degree of difference in anti oxidant response of body and brain against radiation exposure.