Neuroinflamatory Evidence During Early Onset of Depression in CMS Rats as Detected by Proton MRS at 7T.

Hemanth Kumar B.S. ¹, Sushanta Kumar Mishra¹, Poonam Rana¹, Sadhana Singh¹, Rajendra P. Tripathi¹, Subash Khushu¹

Chronic Mild Stress (CMS) regime was applied to develop depression model in rats and the model was validated using behavioural studies. Magnetic Resonance Spectroscopy (MRS) was acquired on 10 Control and CMS induced rats in prefrontal cortex (PFC) and hippocampus regions to look for the neurometabolite changes duing the early onset of depression. The concentrations of the neurometabolites were calculated for analysis. The study revealed the metabolite fluctuations, altering the glial physiology within prefrontal cortex and hippocampus in CMS model. We conclude that there might be a neuroinflamation process ocucuring in the glia and the neurons of these brain regions to play a major role in onset of depression.