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Abstract #4440

Methylphenidate's Effects on the Metabolomic Profile of the Rat Brain Measured by 1H-MRS

Hedok Lee1, Shaonan Zhang1, Mei Yu1, Rany Makaryus1, David Smith2, Nora Volkow3, Helene Benveniste1

1Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, United States; 2Medical, Broohaven National Laboratory, Upton, NY, United States; 3National Institute on Drug Abuse, Bethesda, MD, United States

There is lack of information as to the short- and long-term effects of MP on brain function and neurotransmission. In this study, we employed proton magnetic resonance spectroscopy (1HMRS) to characterize neurochemical status in the rodent brain anesthetized with isoflurane before and after an intravenous challenge with IV dose of 5mg/kg MP. We found significantly decreased [Glu] in the rat striatum. This is in agreement with human studies demonstrating that MP can decrease CMRglu in some individuals an effect that is accentuated under conditions of higher glucose demand.