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Abstract #4444

Magnetic Resonance Spectroscopy in Obsessive-Compulsive Disorder: Comparing Brain Metabolism in Selective Serotonin Responders and Non-Responders

Mona Adel Mohamed1, Richard Edden1, Manuel Uy2, Gerald Nestadt3, Peter Barker1

1Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States; 2Applied Physics Laboratory, Johns Hopkins University, Baltimore, MD, United States; 3Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD, United States

Through magnetic resonance spectroscopy (MRS), significant differences were found in myoinositol (mI) concentrations in the anterior cingulate cortex (ACC) of OCD patients as compared to controls, as well as differences in OCD patients who respond to selective serotonin reuptake inhibitors (SSRIs) and those who do not respond to SSRIs. Significant differences were also found in creatine (Cr) concentrations in the basal ganglia/Thalamus (BG/TH) region between the 2 groups. MRS can be a helpful tool in understanding of the pathophysiology of response to treatment which will lead to the development of new therapeutic approaches.