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Abstract #4449

Brain Biochemical Abnormalities and Cognitive Impairments in Patients with Type 2 Diabetes and Major Depression: A Combined 1H-MRS and Neuropsychological Study

Shaolin Yang1, 2, Olusola Ajilore1, Melissa Lamar1, Laura Korthauer1, Anand Kumar1

1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States

Type 2 diabetes and major depression are mutual risk factors. Previous studies have evidenced brain biochemical abnormalities in cortical and subcortical regions as well as cognitive deficits in patients with either disease alone or both. In order to better understand the pathophysiological mechanisms of these disorders, we examined whether brain biochemical abnormalities measured through 1H magnetic resonance spectroscopy are correlated with cognitive function and performance and whether there is any difference in the correlation profiles among these diseases.