Voxel Selective Lactate Editing at High Magnetic Field Strengths Using Sel-MQC

Gerd Melkus¹, Myriam M. Chaumeil¹, Sharmila Majumdar¹, Sabrina M. Ronen¹

A single voxel localization scheme for the Selective Multiple Quantum Coherence (Sel-MQC) filter for Lactate editing is presented. The method is based on the concept of inducing a spatial mismatch between the J-coupled CH- and CH₃-Lactate resonances to achieve local chemical shift selectivity for the filter. The sequence was tested on a Lactate phantom and compared to LASER and PRESS acquisitions, showing that the theoretical signal intensity of 50% can be achieved using this localization technique for Sel-MQC. A localized Lactate spectrum was acquired at 14.1T from an orthotopic glioblastoma tumor in vivo using this technique.