Localized Two-Dimensional Correlated Spectroscopy Based on Hadamard Encoding Technique

Yanqin Lin¹, Qinta Zhang¹, Shuhui Cai¹, Zhong Chen¹

Localized two-dimensional (2D) magnetic resonance spectroscopy is increasing used in the study of in vivo tissue metabolites. However, long scan time limits its wide applications. Here, a new pulse sequence based on Hadamard encoding technique was devised to speed up the acquisition of 2D correlation spectroscopy. For the new scheme, the direct frequency-domain excitation is used in the indirect detection dimension, so the 2D acquisition was replaced by an array of one-dimensional acquisitions. A phantom built of two concentric glass cylinders was used to demonstrate the feasibility of this new sequence. The new method may provide a time-efficient way for 2D in vivo studies.