Adrienne E. Campbell-Washburn1, 2, Hui Zhang3, Bernard M. Siow1, 3, Anthony N. Price4, Mark F. Lythgoe1, Roger J. Ordidge5, David L. Thomas6
1Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, United Kingdom; 2Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom; 4Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom; 5Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia; 6Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
This study presents multi-slice cardiac arterial spin labelling using a new method of myocardial blood flow (MBF) quantification with blood pool magnetization measurement (bpMBF quantification). For bpMBF quantification, a direct measurement of the left-ventricle blood pool magnetization was used to approximate the blood input function into the Bloch equations. Simulation and in vivo results show that bpMBF quantification is robust to variations in slice-selective thickness and therefore applicable to multi-slice acquisition, whereas traditional methods are likely to underestimate multi-slice perfusion. This technique is applied to generate the first multi-slice MBF maps using cardiac arterial spin labelling.