1Sir
Peter Mansfield Magnetic Resonance Centre, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom; 2Department of
Nephrology, University Hospital Basel, Basel, Switzerland; 3Department
of Cardiovascular Sciences, University of Leicester, Leicester,
Leicestershire, United Kingdom; 4Department of Renal Medicine,
Royal Derby Hospital, Derby, Derbyshire, United Kingdom
Diffusion and perfusion in the kidneys are assessed in cardiorenal syndrome (CRS) patients and healthy volunteers in order to determine whether renal dysfunction in CRS is due to changes in tissue structure (fibrosis) or haemodynamic changes. Strong correlations are found between ADC, fpD*, renal artery flux and cortical perfusion with eGFR. We find that flow (fpD*) contributes to the changes in ADC, but structural changes indicated by a change in T1 are not reflected in D alone.
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