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Abstract #0024

Changes in Intrarenal Oxygenation as Evaluated by BOLD MRI in a Rat Biliary Obstruction Model

Mingshu Yang1, Min Ji1, Bin Yang1, Li Wang1, Chunmei Xia2, Lixia Yang3, Zhongwei Qiao1, Ed X. Wu4

1Department of Radiology, Children Hospital of Fudan University, Shanghai, China; 2Department of Physiology and Pathophysiology, Fudan University, Shanghai, China; 3Department of Radiology, Xuhui Center Hospital, Shanghai, China; 4Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Blood oxygenation level-dependent (BOLD) MRI was shown to allow non-invasive observation of renal oxygenation. Experimental bile duct ligation has been widely used as an animal model to evaluate the renal molecular changes. This study aims to investigate the alteration of R2* in the kidney of rat induced by biliary duct ligation. We observed that the medullary R2* in model group is higher than that in controls, but the difference in cortical R2* was not significant between two groups. Our results implicated that acute biliary obstruction induced by bile duct ligation caused an alteration of renal medullar oxygenation.