Abstract #0038

Intrinsic Connectivity Network Activity Revealed by the Independent Modelling of the Primary and Post-Stimulus Components of the BOLD Response

Karen J. Mullinger¹, Stephen D. Mayhew², Andrew P. Bagshaw², Richard W. Bowtell³, Susan T. Francis³

¹SPMMRC, School of Physics and Astronomy , University of Nottingham, Nottingham, United Kingdom; ²BUIC, School of Psychology, University of Birmingham, Birmingham, United Kingdom; ³SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

Intrinsic connectivity networks (ICNs) exist during both stimulation and rest, however little is known about the changes in their activity in the transition between task and rest. Simultaneous EEG-BOLD measures provide an interesting new method to study this transition. We demonstrate that during median-nerve stimulation BOLD modulations, indexed by EEG mu power, occur over a number of ICNs, whilst post-stimulus modulations are specific to the bilateral sensorimotor network. We hypothesize that the post-stimulus activity represents re-setting of the entire sensorimotor network, providing a mechanism for this ICN to return to resting-state activity from the lateralised activity driven by stimulation.