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Abstract #0046

Spatial Patterns of Cortical Thinning in Neuromyelitis Optica: A Comparative Study with Multiple Sclerosis

Yaou Liu1, Teng Xie2, Ni Shu2, Kuncheng Li1, Yong He2

1Department of Radiology, Xuanwu hospital, Capital Medical University, Beijing, China; 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

We analyzed the global and regional cortical thickness (CTh) in patients with neuromyelitis optica (NMO), and directly compared with multiple sclerosis (MS) and healthy controls (HCs). Different patterns of cortical thinning between MS and NMO were observed. MS showed a widespread cortical thinning in many brain regions predominantly in frontal and temporary lobes, while subtle cortical thinning in occipital lobe was observed compared with HCs. When directly compare MS and NMO, several brain regions in temporary lobe was found significantly thinner in MS. Furthermore a significant correlation was found between CTh in several brain regions and clinical variables.