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Abstract #0048

Regional Cortical Thickness in Relapsing Remitting Multiple Sclerosis: A Multi-Center Study

Ponnada A. Narayana1, Koushik Govindarajan1, Priya Goel1, Sushmita Datta2, John A. Lincoln3, Stacy S. Cofield4, Gary R. Cutter4, Fred D. Lublin5, Jerry S. Wolinsky3

1Diagnostic and Interventional Imaging, University of Texas Hlth Sci Cntr Houston, Houston, TX, United States; 2Diagnostic and Interventional Imaging, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States; 3Neurology, University of Texas Hlth Sci Cntr Houston, Houston, TX, United States; 43Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States; 5The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, United States

Changes in regional and global cortical thickness and age- and gender dependence of these measures on a large MS cohort that is a part of a multi-center clinical trial were investigated. Changes in regional cortical thicknesses were larger in the left hemisphere compared to the right. Males showed stronger age dependent cortical thickness than females. Strongest reductions in the thickness were observed in the entorhinal cortex and temporal poles in MS, the structures implicated in several neurodegenerative diseases. Weaker age dependent changes in both global and regional cortical thicknesses were observed in MS patients compared to controls.