Abstract #0050

Impact of Macrophagic Activity on Tissue Structure in Patients Suffering from Clinically Isolated Syndrome Suggestive of Multiple Sclerosis: A Multicentric USPIO Enhancement Study at 3T

Adil Maarouf¹,², Jean Christophe Ferr³,⁴, Wafaa Zaaraoui¹, Elise Bannier⁵, Christian Barillot⁶, Isabelle Berry⁷, Gilles Edan⁸, Damien Galanaud⁹, Jean Pelletier,¹¹⁰, Christophe Portefaix¹¹, Ayman Tourbah¹², Jean-Philippe Ranjava¹, Bertrand Audoin,¹¹⁰

¹CRMBM, CNRS UMR 7339, Marseille, France; ²Dept. of Neurology, CHU REIMS, Reims, France; ³Dept. of Neuroradiology, CHU Rennes, RENNES cedex 9, France; ⁴Visages U746 , INSERM INRIA IRISA, Rennes, France; ⁵Neurinfo, INSERM INRIA IRISA, Rennes, France; ⁶Visages U746, INSERM INRIA IRISA, Rennes, France; ⁷Dept. of Biophysics, CHU Toulouse, Toulouse, France; ⁸Dept. of Neurology, CHU Rennes, Rennes, France; ⁹Dept of Neuroradiology, Piti Salptrire Hospital, Paris, France; ¹⁰Dept. of Neurology, CHU Marseille, Marseille, France; ¹¹Dept. Radiology, CHU Reims, Reims, France; ¹²Dept. of Neurology, CHU Reims, Reims, France

Macrophage infiltration is an important pattern in inflammatory processes associated to multiple sclerosis. The aim of this longitudinal and multicentric study was to determine the prevalence of USPIO enhancement in patients with early MS and the impact of macrophage activity at early and medium term on tissue integrity assessed by MTR. From the earliest stage of MS, we highlighted the presence in vivo of activated macrophages. Destructuration was higher and persistent in lesions with significant macrophages burden. The total T2-w lesion was significantly higher in the group of patient that had at baseline at least one USPIO-positive lesion.